Wall, Gerard

NFB-SRC Principal Investigator

Department of Microbiology,
National University of Ireland,

00353 (0) 91 49 5808

 Research Interests

  • Production of recombinant proteins (including membrane proteins and glycoproteins) in E. coli, P. pastoris and cell-free systems; optimisation of production of therapeutic and biotechnologically important proteins through the use of, e.g., metabolic and protein engineering, co-production of molecular chaperones
  • Antibody-directed tumour therapy: use of molecular evolution and modelling/directed mutagenesis techniques to generate novel variants of mammalian enzymes in E. coli for use in ADEPT; production in E. coli, P. pastoris and cell-free systems
  • Study of protein folding and chaperones in extremophilic microorganisms
  • Immunosensor development: production and engineering (affinity maturation, increasing stability) of antibody fragments in E. coli for use in immunosensors; investigation of novel supports for protein immobilisation
  • Functional biomaterials: use of phage and peptide libraries to direct biodegradable nanoshells to specific cell types for targeted gene delivery

Professional Qualifications and Appointments

Jan 2008 Department of Microbiology, NUI Galway
1996-2007 Assistant Lecturer ('96-'00), Lecturer ('00-'07), Senior Lecturer ('07), Molecular Biology / Immunology, University of Limerick, Ireland
1994-1996 Postdoctoral Fellow, University of Zurich, Switzerland Mentor: Andreas Plückthun
1990-1994 PhD (Molecular Immunology), University of Aberdeen, Scotland. Supervisor: William J. Harris
1986-1990 BSc (1st Hons, Microbiology), NUI Galway

Link to selected Publications

Link to Dr Gerard Wall's Research Profile