Higgins, Brendan

Collaborating Investigator

Department of Physiology,
National University of Ireland,

Research Interests

Acute Lung Injury/Acute Respiratory Distress Syndrome
Gene Delivery to Lung
Vascular Biology

Professional Qualifications

PhD in Physiology, National University of Ireland, Galway


Curley, G., Contreras, M., Nichol, A.D., Higgins, B.D., Laffey, J.G. 'Hypercapnia and acidosis in sepsis: A double-edged sword?' 2010: Anesthesiology. 112(2): 462-472 Link to Pubmed [http://www.ncbi.nlm.nih.gov/pubmed/20068449]
Higgins, B.D., Costello, J., Contreras, M., Hassett, P., O'Toole, D., Laffey, J.G. 'Differential effects of buffered hypercapnia versus hypercapnic acidosis on shock and lung injury induced by systemic sepsis' 2009: Anesthesiology 111(6): 1317-1326 Link to Pubmed [http://www.ncbi.nlm.nih.gov/pubmed/199348
MacLoughlin, R.J., Higgins, B.D., Laffey, J.G., O'Brien, T. 'Optimized aerosol delivery to a mechanically ventilated rodent' 2009: Journal of Aerosol Medicine and Pulmonary Drug Delivery 22(4):323-332 Link to Pubmed [http://www.ncbi.nlm.nih.gov/pubmed/19415985]
O'Toole, D., Hassett, P., Contreras, M., Higgins, B.D., McKeown, S.T.W., McAuley, D.F., O'Brien, T., Laffey, J.G. 'Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-κB dependent mechanism' 2009: Thorax 64(11):976-982 Link to Pubmed [http://www.ncbi.nlm.nih.gov/pubmed/19617214]
Higgins, B., Costello, J., Contreras, M., Ní Chonghaile, M., Hassett, P., O'Toole, D., Laffey, J.G. 'Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis' 2009: Critical Care Medicine 37(8):2412-2420 Link to Pubmed [http://www.ncbi.nlm.nih.gov/pubmed/19531945]
Jarman, J., Maharaj, C.H., Higgins, B.D., Farragher, R.F., Laffey, C.D., Flynn, N.M., Laffey, J.G. 'Role of potassium and calcium channels in sevoflurane-mediated vasodilation in the foeto-placental circulation' 2009: BMC Anesthesiology 9(art. no. 4) Link to Pubmed [http://www.ncbi.nlm.nih.gov/pubmed/19515255]
Maharaj, C.H., O'Toole, D., Lynch, T., Carney, J., Jarman, J., Higgins, B.D., Morrison, J.J., Laffey, J.G. 'Effects and mechanisms of action of sildenafil citrate in human chorionic arteries' 2009: Reproductive Biology and Endocrinology 7(art. no.34) Link to Pubmed [http://www.ncbi.nlm.nih.gov/pubmed/19389232]
Ní Chonghaile, M., Higgins, B.D., Costello, J.F., Laffey, J.G. 'Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism' 2008: Critical Care Medicine 36(12):3135-3144 Link to Pubmed [http://www.ncbi.nlm.nih.gov/pubmed/18936707]
Chonghaile, M., Higgins, B.D., Costello, J., Laffey, J.G. 'Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia' 2008: Anesthesiology 109(5):837-848
Link to Pubmed [http://www.ncbi.nlm.nih.gov/pubmed/18946296]
Kennedy, M.T., Higgins, B.D., Costello, J.F., Curtin, W.A., Laffey, J.G. 'Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury' 2008: BMC Pulmonary Medicine 8(art. no. 9) Link to Pubmed [http://www.ncbi.nlm.nih.gov/pubmed/18611275]
Farragher, R., Maharaj, C.H., Higgins, B.D., Crowe, S., Burke, P., Laffey, C.D., Flynn, N.M., Laffey, J.G. 'Sevoflurane and the feto-placental vasculature: The role of nitric oxide and vasoactive eicosanoids' 2008: Anesthesia and Analgesia 107(1):171-177 Link to Pubmed [http://www.ncbi.nlm.nih.gov/pubmed/18635485]