Biggs, Manus

NFB-SRC Principal Investigator

Network of Excellence for Functional Biomaterials
National University of Ireland
Galway

Phone: 
00353 (0) 91 49 4328

Research Interests

Nanofabrication; Nanolithography; Biomaterials;
Bioengineering; Microelectronics; MEMS platforms;
Cell-Biomaterial Interactions; Cell Adhesion; Biomaterials Characterisation;
Polymer-based Controlled Drug Delivery

Professional Qualifications

Starting Investigator Research Grant Awardee, National University of Ireland, Galway, Ireland
Research Associate, Columbia University, NY, USA
PhD in Tissue Engineering, University of Glasgow, UK
MSc in Biomedical Science, National University of Ireland, Galway, Ireland
BSc in Anatomy, National University of Ireland, Galway, Ireland

Invited Book Chapters

Biggs MJ, Dalby MJ, Wind SJ. ‘Focal adhesion formation and the cellular response at the nanoscale.’ The Nanobiotechnology Handbook (Y. Xie ed.). Boca Raton, FL, CRC Press (2012), 461–486.
Biggs MJ, McNamara L. Stem Cells & Bone Tissue. (R. Rajendram ed) Boca Raton, FL, CRC Press (2013) 125-144
Biggs MJ, Richards RG, Dalby MJ. ‘Using immuno-scanning electron microscopy for simultaneous observation of cell adhesion interaction at the nano/microscale in S-phase cells. 3D Cell Culture’ Methods in Molecular Biology. 2011: 695, 53-60.

Publications

Vallejo-Giraldo C, Kelly A, Biggs MJ ‘Biofunctionalisation of electrically conducting polymers.’ Drug Discovery Today. 2013 (In Press)
McNamara LE, Burchmore R, Riehle MO, Herzyk P, Tsimbouri PM, Biggs MJ, Wilkinson CDW, Curtis ASG, Dalby MJ. ‘Non-invasive investigation of direct nuclear mechanotransduction – linking changes in nuclear architecture to small RNA, transcript and protein abundance.’ Biomaterials. 2012: 33, 2835–2847.
Biggs MJ, Gondarenko A, Milone MC, Santos L, Wind SJ. ‘High resolution imaging of the immunological synapse and TCR microclustering through micro fabricated substrates’ Journal of the Royal Society Interface. 2011: 8(63), 1462-1471.
Biggs MJ, Dalby MJ. ‘Nanotopographical modification: a regulator of cellular function through focal adhesions.’ Nanomedicine. 2010: 6(5), 619-633.
Biggs MJ, Dalby MJ. ‘Focal adhesions in osteoneogenesis.’ Journal of Engineering in Medicine. 2010: 224(Part H), 1441-1453.
McNamara L, McMurray RJ, Biggs MJ, Kantawong F, Oreffo ROC, Dalby MJ. ‘Nanotopographical control of stem cell differentiation.’ Journal of Tissue Engineering. 2010: 120623.
Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Oreffo RO, Dalby MJ. ‘The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+ enriched skeletal stem cells.’ Biomaterials 2009: 30, 5094-5103.
Biggs MJ, Richards RG, Gadegaard N, McMurray RJ, Affrossman S, Wilkinson CD, Oreffo RO, Dalby MJ. ‘Interactions with nanoscale topography: Adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage.’ Journal of Biomedical Materials Research: Part A. 2009: 91(1), 195-208.
Biggs MJ, Richards RG, Wilkinson CD, Dalby MJ. ‘Focal adhesion interactions with nanostructures: A novel method for immuno-SEM labelling of focal adhesions in S-phase cells.’ Journal of Microscopy. 2008: 231, 28-37.
Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Oreffo ROC, Affrossman S, Dalby MJ. ‘Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330 nm deep microgrooves.’ Journal of the Royal Society Interface. 2008: 27(5), 1231-1242.
Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Dalby MJ. ‘The effects of nanoscale pits on primary human osteoblast adhesion formation and cellular spreading.’ Journal of Materials Science: Materials in Medicine. 2007: 18, 399-404.
Dalby MJ, Biggs MJ, Gadegaard N, Kalna G, Wilkinson CD, Curtis AS. ‘Nanotopographical stimulation of mechanotransduction and changes in interphase centromere positioning.’ Journal of Cellular Biochemistry. 2006: 100(2), 326-338.
Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Dalby MJ. ‘Regulation of implant surface cell adhesion: characterization and quantification of S-phase primary osteoblast adhesions on biomimetic nanoscale substrates.’ Journal of Orthopaedic Research. 2006: 25(2), 273-282.

Link: Galway Neuroscience Centre